Abstract acute generalized exanthematous pustulosis agep is a rare druginduced skin disorder. Acute generalized exanthematous pustulosis agep is a rare, acute eruption characterized by the development of numerous nonfollicular sterile pustules on a background of edematous erythema. Acute generalized exanthematous pustulosis agep is an uncommon disorder characterized by an acute episode and sudden onset of erythematous and edematous eruptions of hundreds of sterile pustules. Acute generalised exanthematous pustulosis agep is a severe cutaneous adverse reaction and is attributed to drugs in more than 90% of cases. Pdf pustulosis exantematica generalizada aguda inducida por. Pustulosis exantematica generalizada aguda asociada a scielo. Clinically, agep is characterized by small nonfollicular, sterile pustules on an ery. Between 62 and 90% of cases of acute generalized exanthematous pustulosis are caused by drugs. Acute generalized exanthematous pustulosis agep is a severe, usually drugrelated reaction, characterized by an acute onset of mainly small nonfollicular pustules on an erythematous base and spontaneous resolution usually within two weeks. Acute generalized exanthematous pustulosis agep is a druginduced dermatosis characterized by an acute episode of sterile pustules over erythematousedematous skin. Acute generalized exanthematous pustulosis associated with mycoplasma pneumoniae infection. Acute generalized exanthematous pustulosis wikipedia. Its onset is rapid with generalized pustules, fever, and blood neutrophil count over 7000.
Fever and peripheral blood leukocytosis are usually present. Pustulosis exantematica aguda generalizada inducida por. Acute generalized exanthematous pustulosis, ceftriaxone. It is characterized by the rapid onset of disseminated sterile nonfollicular pustules, that are accompanied by fever and marked neutrophilia. It is accompanied by fever and is manifested in patients without a previous history of psoriasis. Pustulosis exantematica generalizada aguda inducida por ceftriaxona. Acute generalized exanthematous pustulosis agep also known as pustular drug eruption and toxic pustuloderma is a rare skin reaction that in 90% of cases is related to medication administration agep is characterized by sudden skin eruptions that appear on average five days after a medication is started. Summary acute generalized exanthematous pustulosis agep is a not microbial pustular rash of acute onset and usually associated with the ingestion of drugs in patients without history of psoriasis. Other diseases can express similarly, and the differential diagnosis between them may be difficult. Pustulosis aguda generalizada actas dermosifiliograficas. Introduccion l a pustulosis exantematica generalizada aguda pega fue descrita por primera vez en 1980 por beylot. It is a rare disease, with an estimated incidence of 15 patients per million per year.
Pustulosis exantematica generalizada aguda inducida por. It is accompanied by an episode of fever, which regresses a few days after discontinuation of the drug that caused the condition or as a result of corticosteroid treatment. Scarce reports exist regarding non drugrelated acute generalized exanthematous pustulosis, the tri. It is characterized by the rapid onset of disseminated sterile nonfollicular pustules, that are accompanied by fever and marked. Antibiotics are the most commonly implicated drugs.
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